AR-12 Inhibits Chaperone Proteins Preventing Virus Replication and the Accumulation of Toxic Misfolded Proteins
نویسندگان
چکیده
Although originally thought to be an inhibitor of PDK-1, OSU-03012 (AR-12) was shown in 2005 not to primarily act as a PDK-1 inhibitor in its ability to radio-sensitize tumor cells [1,2]. Subsequently it was shown that the primary mechanism by which AR-12 killed tumor cells was via the PKR-like endoplasmic reticulum kinase (PERK) -dependent induction of endoplasmic reticulum stress signaling [1–3]. ER stress signaling in turn promoted a toxic form of autophagy resulting in a necroptotic form of cell death.
منابع مشابه
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عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2016